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Genesis Scientific Publication is an International open access publication house. It is a platform who promotes and intends to publish high quality scientific research from all over the globe. Genesis is an open access, internationally peer-reviewed publishers that are indulged in publishing original articles with an emphasis on the most recent research discoveries.

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Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi², Carmen Austrália Paredes Marcondes Ribas³

A Three-Tier Framework for Orthobiologic Use in Arthrosis and Lumbar Degeneration: Separating What Is Proven Safe and Effective from What Is Merely Proven Safe

Background: Orthobiologic injections are offered to patients with arthrosis and degenerative lumbar disease on the strength of a large and reassuring safety literature. Safety and efficacy are, ..

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Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi² and Carmen Austrália Paredes Marcondes Ribas³

A Comprehensive Meta-Analysis of Orthobiologics in Arthrosis and Lumbar Degeneration: Moderate Symptomatic Benefit, Comparator-Dependent Effects and an Evidence-Tiered Framework for Clinical Practice

Background: Orthobiologic injections — platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), adipose-derived and bone marrow-derived mesenchymal stromal cells (MSC), ..

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Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi² and Carmen Austrália Paredes Marcondes Ribas³

Centrifugation Determines What Is in the Syringe, Not What Happens to the Patient: A Systematic Meta-Analysis of Platelet-Rich Plasma Preparation, Platelet Integrity, Cell Counts, Growth Factors and Clinical Outcomes in Regenerative Medicine

Background: Platelet-rich plasma (PRP) is prepared with centrifugation protocols that differ by more than an order of magnitude in relative centrifugal force and by a factor of eight in spin time. It ..

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Marcio Hiroaki Kume^1*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi² and Carmen Austrália Paredes Marcondes Ribas³

Ultrasound-Guided Caudal Epidural Injections for Single-Level Lumbar Spinal Stenosis: A Randomised, Double-Blind Clinical Trial Comparing Platelet-Rich Plasma, Bone Marrow Aspirate, Corticosteroid and Combination Regenerative Therapies

Background: Epidural corticosteroid injection remains the most widely used interventional treatment for symptomatic lumbar spinal stenosis, yet its benefit is short lived and repeated exposure ..

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Mike KS Chan ^1,2,3, Michelle BF Wong ^1,2, Krista Casazza ⁴ and Jonathan RT Lakey ^{2,4 *}

A Systems-Level Therapeutic Platform Integrating Neural Progenitors, Mitochondrial Medicine, and Organ-Specific Biologics

Traumatic spinal cord injury (SCI) remains one of the greatest challenges in regenerative medicine because neurological recovery is limited by complex interactions among neuronal loss, mitochondrial ..

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Pedro Gutierrez-Castrellon¹⁵, Carolina Bluguermann², Ian Jenkins³, Krista Casazza⁴, Bradley Robinson⁵, Adrian Mutto², Jonathan R. T. Lakey³⁴⁵*

Chondrocyte and Mesenchymal Stem Cell–Based Regenerative Therapies for Osteoarthritis and Degenerative Bone Disorders

Background Osteoarthritis (OA) and related degenerative osteochondral disorders are driven by chondrocyte dysfunction, extracellular-matrix degradation, synovitis and subchondral-bone remodelling. ..

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