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Genesis Scientific Publication

Genesis Scientific Publication is an International open access publication house. It is a platform who promotes and intends to publish high quality scientific research from all over the globe. Genesis is an open access, internationally peer-reviewed publishers that are indulged in publishing original articles with an emphasis on the most recent research discoveries.

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Pedro Gutiérrez-Castrellón^1,5*, Juan M.A. Garcia-Lara², Diana M. Andrade-Platas^1,2, Bradley Robinson⁵ and Jonathan RT Lakey^1,4,5*

Efficacy and Safety of Tesamorelin for Hepatic Steatosis in Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease a Systematic Review, Random-Effects Meta-Analysis and Placebo-Anchored Network Meta-Analysis with SUCRA Ranking

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, yet the pharmacological armamentarium remains narrow and only one ..

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Márcio Hiroaki Kume¹^*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi² and Carmen Austrália Paredes Marcondes Ribas³

Comprehensive Comparative Study of Four Bone Marrow Aspiration Techniques in Regenerative Medicine: Yield, Procedure Time, and Morbidity in a 240-Patient Randomized Trial

Background: Autologous bone marrow aspirate concentrate (BMAC) is a cornerstone of musculoskeletal regenerative medicine, and its therapeutic potency is determined largely by the harvest technique. ..

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Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi², Carmen Austrália Paredes Marcondes Ribas³

Optimization of Single-Spin Platelet-Rich Plasma Preparation: A Comparative Analysis of Centrifugation Parameters on Cellular Composition and Growth Factor Content

Background: Platelet-rich plasma (PRP) is prepared with widely divergent centrifugation protocols, and the resulting products differ so much in platelet yield, leukocyte content and growth factor ..

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Márcio Hiroaki Kume¹^*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi², Carmen Austrália Paredes Marcondes Ribas³

Comparative Analysis of Bone Marrow Aspirate Concentrate, Adipose-Derived Mesenchymal Stromal Cells, and Combined Therapy (PRP + BMAC + Adipose MSCs) for Knee Osteoarthritis: A 250-Patient Randomized Controlled Trial with 24-Month Follow-Up

Background: Intra-articular orthobiologics are widely used for knee osteoarthritis (OA), but platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC) and adipose-derived mesenchymal ..

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Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi², Carmen Austrália Paredes Marcondes Ribas³

Impact of Adipose-Derived Mesenchymal Stem Cell Isolation Parameters on Cell Yield, Growth Factor Secretion, and Clinical Outcomes in Knee Osteoarthritis: A Randomized Controlled Trial

Background: Intra-articular injection of adipose-derived mesenchymal stem cells (AD-MSCs) is increasingly offered for symptomatic knee osteoarthritis, but the laboratory step that converts ..

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Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi², Carmen Austrália Paredes Marcondes Ribas³

A Three-Tier Framework for Orthobiologic Use in Arthrosis and Lumbar Degeneration: Separating What Is Proven Safe and Effective from What Is Merely Proven Safe

Background: Orthobiologic injections are offered to patients with arthrosis and degenerative lumbar disease on the strength of a large and reassuring safety literature. Safety and efficacy are, ..

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